Genetic nomenclature for Trypanosoma and Leishmania.
نویسندگان
چکیده
Christine Clayton *, Mark Adams , Renata Almeida , Théo Baltz , Mike Barrett , Patrick Bastien , Sabina Belli , Stephen Beverley , Nicolas Biteau , Jenefer Blackwell , Christine Blaineau , Michael Boshart , Frederic Bringaud , George Cross , Angela Cruz , Wim Degrave , John Donelson , Najib El-Sayed , Gioliang Fu , Klaus Ersfeld , Wendy Gibson , Keith Gull , Alasdair Ivens , John Kelly , Daniel Lawson , John Lebowitz , Phelix Majiwa , Keith Matthews , Sara Melville , Gilles Merlin , Paul Michels , Peter Myler , Alan Norrish , Fred Opperdoes , Barbara Papadopoulou , Marilyn Parsons , Thomas Seebeck , Deborah Smith , Kenneth Stuart , Michael Turner , Elisabetta Ullu , Luc Vanhamme aa
منابع مشابه
Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing.
A number of mitochondrial proteins have been identified in Leishmania sp. and Trypanosoma brucei that may be involved in U-insertion/deletion RNA editing. Only a few of these have yet been characterized sufficiently to be able to assign functional names for the proteins in both species, and most have been denoted by a variety of species-specific and laboratory-specific operational names, leadin...
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In this study we analyze and compare the trends in codon usage in five representative species of kinetoplastid protozoans (Crithidia fasciculata, Leishmania donovani, L. major, Trypanosoma cruzi and T. brucei), with the purpose of investigating the processes underlying these trends. A principal component analysis shows that the G+C content at the third codon position represents the main source ...
متن کاملGenetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma
Aminoglycoside antibiotics target the ribosomal decoding A-site and are active against a broad spectrum of bacteria. These compounds bind to a highly conserved stem-loop-stem structure in helix 44 of bacterial 16S rRNA. One particular aminoglycoside, paromomycin, also shows potent antiprotozoal activity and is used for the treatment of parasitic infections, e.g. by Leishmania spp. The precise d...
متن کاملKinetoplastid-specific histone variant functions are conserved in Leishmania major.
Regions of transcription initiation and termination in kinetoplastid protists lack known eukaryotic promoter and terminator elements, although epigenetic marks such as histone variants and the modified DNA base J have been localized to these regions in Trypanosoma brucei, Trypanosoma cruzi, and/or Leishmania major. Phenotypes of base J mutants vary significantly across trypanosomatids, implying...
متن کاملHeterologous expression of Trypanosoma cruzi trans-sialidase in Leishmania major enhances virulence.
Earlier studies showed that mice primed for a few hours with the trans-sialidase (TS) of Trypanosoma cruzi, the agent of Chagas' disease, become highly susceptible to trypanosomal infection. These studies suggest that TS affects parasite virulence independent of antigenic stimulation. Potentially, TS could enhance or reduce the virulence of heterologous microbes depending on the mechanism of TS...
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عنوان ژورنال:
- Molecular and biochemical parasitology
دوره 97 1-2 شماره
صفحات -
تاریخ انتشار 1998